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Biopolymers are gaining increasing attraction as an avenue for developing absorbable oral matrices for pharmaceuticals. Zein, the main storage protein in corn, has huge potential, particularly because it is hot-melt-processable and can interact with therapeutically-active compounds.

In parallel, dual active pharmaceutical ingredient-ionic liquids (API-IL) hold huge promise for future drugs, as they can be easily dosed and processed to prepare stable pharmaceuticals that can quickly cross through cell walls.

Including an  API-IL in a biopolymer matrix, such as plasticized zein, not only facilitates shaping into form but also helps ensure targeted delivery and controlled release.

The purpose of this study was to engineer a resorbable material from zein and address its ability to release Lidbu as a dual API-IL.